How long before the effects of TRT work...you ask?
Information compiled by gdevine
We see this question asked a lot! I believe it's different for all men for a ton of reasons (see conclusion below) BUT there's been enough studied on it that some clinical guide lines can be established:
See this study:
ONSET OF EFFECTS OF TESTOSTERONE TREATMENT AND TIME SPAN UNTIL MAXIMUM EFFECTS ARE ACHIEVED.
Eur J Endocrinol. 2011 Jul 13;
Authors: Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren LJ
Objectives: Testosterone has a spectrum of effects on the male organism. This review attempts to determine, from published studies, the time-course of the effects induced by testosterone replacement therapy from their first manifestation until maximum effects are attained.
Design: Studies in PubMed on testosterone replacement so far providing information on time course.
Results:
- Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.
- Changes in erections/ejaculations may require up to 6 months.
- Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.
- Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.
- First effects on erythropoiesis after 3 months, peaking at 9-12 months.
- Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.
- Effects on lipids appear after 4 weeks, maximal after 6-12 months.
- Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 3-12 months.
- Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.
- Effects on inflammation occur within 3 to 12 weeks.
- Effects on bone detectable after 6 months but continue at least for 3 years.
Conclusion: the time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation. Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity.
PMID: 21753068 [PubMed - as supplied by publisher]
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