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Thread: How long before the effects of TRT work...you ask?

  1. #1
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    How long before the effects of TRT work...you ask?

    Information compiled by gdevine


    We see this question asked a lot! I believe it's different for all men for a ton of reasons (see conclusion below) BUT there's been enough studied on it that some clinical guide lines can be established:

    See this study:

    ONSET OF EFFECTS OF TESTOSTERONE TREATMENT AND TIME SPAN UNTIL MAXIMUM EFFECTS ARE ACHIEVED.

    Eur J Endocrinol. 2011 Jul 13;

    Authors: Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren LJ

    Objectives: Testosterone has a spectrum of effects on the male organism. This review attempts to determine, from published studies, the time-course of the effects induced by testosterone replacement therapy from their first manifestation until maximum effects are attained.

    Design: Studies in PubMed on testosterone replacement so far providing information on time course.

    Results:
    • Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.
    • Changes in erections/ejaculations may require up to 6 months.
    • Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.
    • Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.
    • First effects on erythropoiesis after 3 months, peaking at 9-12 months.
    • Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.
    • Effects on lipids appear after 4 weeks, maximal after 6-12 months.
    • Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 3-12 months.
    • Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.
    • Effects on inflammation occur within 3 to 12 weeks.
    • Effects on bone detectable after 6 months but continue at least for 3 years.


    Conclusion: the time-course of the spectrum of effects of testosterone shows considerable variation, probably related to pharmacodynamics of the testosterone preparation. Genomic and non-genomic effects, androgen receptor polymorphism and intracellular steroid metabolism further contribute to such diversity.

    PMID: 21753068 [PubMed - as supplied by publisher]


    Further discussion is also available at:

    [URL="http://forums.steroid.com/hormone-replacement-therapy-low-testosterone-treatment-anti-aging/476788-how-long-before-effects-trt-work-you-ask.html"]How long before the effects of TRT work...you ask?[/URL]
    Tired likes this.
    [URL="http://www.lowtestosterone.com/"][/URL]

  2. #2
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    good read admin!

    I'm assuming this is all based on a standard long esther, like cyp or E?

  3. #3
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    Excellent! Thanks for posting this.

  4. #4
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    Thanks for sharing!
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